Best Fit Profiles
- homocysteine reduction, methylation support, and liver health protocols
Methylation support and homocysteine reduction
TMG (Trimethylglycine / Betaine)
TMG is a methyl donor that supports one-carbon metabolism and reduces homocysteine. RCTs show meaningful homocysteine reduction as an adjunct to B vitamins. Also studied for exercise performance and liver health.
Evidence Level B
Evidence and Risk Labels
Evidence A/B/C reflects research maturity, and risk levels reflect monitoring needs. These labels support comparison, not diagnosis or treatment decisions.
See full scoring guideClinical Snapshot
- Effect Size
- Moderate homocysteine reduction; modest exercise performance effect; meaningful liver fat reduction in NAFLD
- Safety
- Low Risk
High doses (6+ g/day) may increase LDL in some individuals; fishy body odor is a benign but notable side effect at high doses due to TMAO conversion.
Research Dosing
This reflects common ranges and protocols used in published studies, not personal medical advice.
- Typical Daily Dose
- 500-3000 mg
- Timing
- With meals
- Protocol Duration in Studies
- 8-12 weeks minimum for homocysteine endpoints
Often combined with folate and B12 for comprehensive methylation support.