Feb 12, 2026TMG (Trimethylglycine): Methylation Support, Homocysteine Reduction, and Exercise EvidenceTMG (trimethylglycine/betaine) donates methyl groups to lower homocysteine and supports the methylation cycle alongside B12 and folate. It also shows consistent exercise performance benefits in multiple RCTs — a dual-purpose compound with a clean safety profile.