Feb 13, 2026Alpha-Ketoglutarate and Aging: TET Enzyme Activity, Epigenetic Clocks, and Ca-AKG TrialsAlpha-ketoglutarate (AKG) is a TCA cycle intermediate that activates TET enzymes involved in DNA demethylation. The TRIIM-X trial using Ca-AKG reported a reduction in biological age markers. Evidence is preliminary but mechanistically credible.