Feb 8, 2026Mitochondria and Aging: Bioenergetics, ROS, Fission/Fusion Dynamics, and Intervention TargetsMitochondrial dysfunction is a central hallmark of aging. ATP production efficiency declines, ROS production increases, and the balance of fission (fragmentation) and fusion (elongation) shifts unfavorably. This article explains the biology and maps interventions — from CoQ10 to urolithin A — to specific mitochondrial nodes.