Feb 17, 2026Caloric Restriction Mimetics in 2025: Multi-Pathway Geroprotectors Under Clinical EvaluationA 2025 Biogerontology review maps geroprotective compounds targeting AMPK, mTOR, and autophagy pathways. Most remain at biomarker endpoints; hard longevity data in humans is largely absent.
Feb 17, 2026SIRT3 Activators in Early Clinical Development: Mitochondrial Targets for AgingSIRT3 is a mitochondrial deacetylase linked to energy efficiency and oxidative stress resistance. Novel small-molecule SIRT3 activators are in preclinical development; human efficacy data does not yet exist.