Feb 24, 2026SIRT3 and Mitochondrial Integrity: NAD-Dependent Deacetylase, Caloric Restriction Mimicry, and ActivatorsSIRT3 is the primary mitochondrial sirtuin — a NAD-dependent deacetylase that regulates ATP synthesis, ROS detoxification, and fatty acid oxidation. Its activity declines with age and NAD+ depletion. Activators include honokiol, urolithin A, and exercise, though human trial data is thin.
Feb 10, 2026Nicotinamide Riboside and Nicotinamide: NAD+ Precursor Comparison and Human Trial EvidenceNicotinamide riboside (NR) and plain nicotinamide both raise NAD+ but through different pathways and with different safety profiles. NR has more published human trials; nicotinamide is cheaper but raises sirtuin-inhibition concerns at high doses.
Feb 9, 2026Apigenin: CD38 Inhibition, NAD+ Preservation, and Sleep EvidenceApigenin inhibits CD38, an enzyme that consumes NAD+ — positioning it as an indirect NAD booster. It also has mild sleep-promoting and senolytic properties. Human evidence is limited but mechanistic rationale is solid.