Feb 20, 2026Elevated Homocysteine Risk: Evidence for Vitamin B12 and TMG StrategiesHomocysteine is a useful risk-context biomarker. B-vitamin repletion and trimethylglycine can lower levels reliably, but clinical-outcome benefit depends on baseline risk and protocol quality.
Feb 19, 2026Vitamin B12: Deficiency in Aging, Neurological Consequences, and Supplement Form EvidenceB12 deficiency affects 10–30% of adults over 50, largely due to reduced gastric acid and intrinsic factor. Deficiency causes irreversible neurological damage if uncorrected. Methylcobalamin and adenosylcobalamin are preferred over cyanocobalamin for neurological applications. High-dose oral B12 can bypass intrinsic factor.
Feb 12, 2026TMG (Trimethylglycine): Methylation Support, Homocysteine Reduction, and Exercise EvidenceTMG (trimethylglycine/betaine) donates methyl groups to lower homocysteine and supports the methylation cycle alongside B12 and folate. It also shows consistent exercise performance benefits in multiple RCTs — a dual-purpose compound with a clean safety profile.
Jan 24, 2026Homocysteine and Methylation: B12, Folate, TMG — Cardiovascular Risk and ProtocolElevated homocysteine is an independent cardiovascular and cognitive risk factor. The methylation pathway requires adequate B12, folate (as methylfolate in MTHFR variants), and TMG as a methyl donor. Correction is straightforward when deficiency is identified.
Jan 22, 2026Glycine: Collagen Synthesis, Sleep Quality RCTs, and Methylation SupportGlycine is conditionally essential in older adults. RCTs show meaningful improvement in sleep quality and morning alertness at 3g doses. It is also the rate-limiting substrate for collagen synthesis and a methyl group buffer in methylation pathways.