Feb 5, 2026mTOR, AMPK, and SIRT1: Longevity Pathway Switches and How Supplements Modulate ThemThree interlocked pathways — mTOR (growth/anabolism), AMPK (energy sensing), and SIRT1 (NAD-dependent deacetylase) — function as master longevity regulators. Supplements like rapamycin, berberine, and NMN modulate them through distinct entry points. Understanding the pathway logic prevents counterproductive stacking.