Feb 11, 2026Longevity Gene Activation: SIRT1, AMPK, mTOR, and NRF2 — Compound-by-Compound Evidence MapFour gene networks — SIRT1 (longevity deacetylase), AMPK (energy sensor), mTOR (growth regulator), and NRF2 (antioxidant response) — are the primary longevity targets for supplement intervention. This article maps which compounds activate which genes, the quality of evidence, and where interactions become relevant.