Feb 9, 2026Supplement Timing and Dosing: When Evidence Shows It Matters — Fat-Soluble, Circadian, and Meal ContextFor most supplements, timing has modest impact. For fat-soluble vitamins (D, K, E, A), a fatty meal meaningfully improves absorption. For melatonin, CoQ10, and some adaptogens, circadian timing matters. For creatine and protein, peri-workout timing is relevant.