Feb 9, 2026Calcium Alpha-Ketoglutarate and Epigenetic Aging: Biological Age Reduction EvidenceCalcium alpha-ketoglutarate (Ca-AKG) is an intermediate in the Krebs cycle and an alpha-ketoglutarate-dependent dioxygenase co-factor critical for epigenetic regulation. A clinical trial showed an 8-year reduction in biological age by DNA methylation clock. Evidence is early but striking.