Feb 24, 2026Intermittent Fasting and Aging: Metabolic Benefits, Muscle Risk, and Evidence ReviewIntermittent fasting (IF) protocols — including 16:8 time-restricted eating and 5:2 alternate-day approaches — produce modest metabolic benefits similar to matched caloric restriction. Autophagy induction is mechanistically plausible but not confirmed in humans at the cellular level during typical IF windows. Muscle mass preservation requires attention to protein timing and resistance training.
Feb 19, 2026Spermidine and Autophagy: Human Evidence, Protocol Context, and UnknownsSpermidine has strong mechanistic and observational support, but randomized human outcome evidence remains limited and ongoing.
Feb 18, 2026POLYCAD Trial: Spermidine Supplementation in Coronary Artery Disease — Design and Interim ContextThe POLYCAD trial is testing 24 mg/day spermidine in 187 older adults with coronary artery disease for 48 weeks. Trial completion is expected August 2026 — no efficacy results exist yet. Prior cohort data from Eisenberg et al. 2016 provides the rationale.
Feb 6, 2026Autophagy Activation Strategies: Spermidine, Fasting, and Exercise — Evidence and ProtocolAutophagy — the cellular recycling process critical for longevity — is activated by caloric restriction, fasting, exercise, and spermidine. This article maps the evidence for each approach, how they interact, and what practical protocols look like when combining these strategies.
Feb 2, 2026Spermidine and Autophagy: Food Sources vs Supplementation, Human Evidence, and Longevity DataSpermidine is the most studied dietary autophagy inducer. Human observational data link higher spermidine intake to reduced all-cause mortality. Supplementation trials are emerging. Wheat germ and other foods provide meaningful amounts but supplements offer dose precision.