2026-02-20
Thyroid Function Variability: Selenium, Zinc, and Myo-Inositol in Clinical Context
Thyroid symptom variability should be managed by medication and lab stability first. Selenium, zinc, and myo-inositol may be adjuncts in selected contexts, not primary treatment.
2026-02-18
CoQ10 and Mitochondrial Function: Age-Related Decline and Clinical Evidence
CoQ10 declines with age and statin exposure. Human evidence is strongest in heart failure and statin-associated muscle symptoms, while prevention use in healthy adults remains less certain.
2026-02-17
SIRT3 Activators in Early Clinical Development: Mitochondrial Targets for Aging
SIRT3 is a mitochondrial deacetylase linked to energy efficiency and oxidative stress resistance. Novel small-molecule SIRT3 activators are in preclinical development; human efficacy data does not yet exist.
2026-02-17
Selenium: Thyroid Function, Antioxidant Enzymes, Cancer Prevention Evidence, and Toxicity Risk
Selenium is an essential trace mineral and key component of glutathione peroxidase and selenoprotein P. It has the strongest evidence base in thyroid autoimmunity (Hashimoto's) and antioxidant enzyme function. The SELECT trial found no cancer prevention benefit from selenium in replete populations — and excess is toxic.
2026-01-14
Zinc Supplementation: Immune Function, Deficiency Detection, and Optimal Forms
Zinc deficiency is common in older adults and impairs innate and adaptive immunity. Supplementation in deficient individuals shows clear benefit; excess zinc is counterproductive and can displace copper.