2026-02-24
Polyphenol Stack Synergy: Quercetin, Resveratrol, Curcumin, and EGCG Combined Evidence
Quercetin, resveratrol, curcumin, and EGCG activate overlapping pathways — NRF2, SIRT1, AMPK, and NFkB inhibition. Stacking them is popular but evidence for synergistic human benefit is largely extrapolated from in vitro and animal models. This article assesses what stacking adds and what it does not.
2026-02-24
Senolytics and Cellular Senescence: Mechanisms, Mayo Clinic Evidence, and Clinical Status
Senolytics are drugs and compounds that selectively clear senescent cells, which accumulate with age and drive chronic inflammation. This review covers the mechanisms, the Mayo Clinic dasatinib+quercetin trials, fisetin evidence, and the current clinical status.
2026-02-20
Osteoarthritis Symptom Load: Boswellia, Curcumin, and Ginger Trial Evidence
Adjunctive supplement evidence in osteoarthritis is strongest for modest pain and function support, with outcomes depending on extract quality, dose, and adherence.
2026-02-19
Polyphenol Protocols in Cognition Clinics: Clinical Context and Evidence Limits
Resveratrol, quercetin, and fisetin are used in some cognition-focused protocols, but human evidence is mixed and best interpreted as adjunctive support rather than primary therapy.
2026-02-19
Resveratrol and Memory Retention: Evidence from a 26-Week Randomized Trial in Older Adults
Witte et al. (2014) found statistically significant memory improvements in adults 50–75 taking 200 mg/day resveratrol for 26 weeks, alongside improved hippocampal connectivity and glucose metabolism. Sample size was small (n=46) and findings require replication.