Best Fit Profiles
- NAD+ restoration as part of longevity and mitochondrial function protocols
NAD+ restoration and cellular energy
Nicotinamide Riboside
NR (nicotinamide riboside) robustly raises blood NAD+ in human trials. Downstream benefits (energy, muscle, cognition) are more modest and inconsistent across trials. Mechanism is established; clinical translation is still being characterized.
Evidence Level B
Evidence and Risk Labels
Evidence A/B/C reflects research maturity, and risk levels reflect monitoring needs. These labels support comparison, not diagnosis or treatment decisions.
See full scoring guideClinical Snapshot
- Effect Size
- Significant NAD+ elevation (40-60% in blood); clinical outcomes more modest and variable
- Safety
- Low Risk
Some individuals report mild flushing; head-to-head with NMN shows similar NAD+ elevation. Long-term safety data is maturing.
Research Dosing
This reflects common ranges and protocols used in published studies, not personal medical advice.
- Typical Daily Dose
- 300-1000 mg
- Timing
- Morning with or without food
- Protocol Duration in Studies
- Ongoing for NAD+ maintenance; 8-12 weeks to assess biomarker response
Tru Niagen (Chromadex NR) is the most studied proprietary form with direct human trial data.