2026-02-22
GERD and Acid Reflux in Aging: Mechanisms, Risks, and Evidence-Based Management
GERD prevalence increases with age and is often overtreated with PPIs, which carry their own risks. This article reviews the mechanisms, evidence-based lifestyle interventions, and where supplements fit.
2026-02-20
High Glycation Burden: Carnosine and Metformin in Clinical Context
Lowering glycation burden is mainly a glucose-control and dietary strategy. Carnosine and metformin may support risk reduction in selected contexts, with different evidence depth and safety constraints.
2026-02-19
Berberine for Metabolic Health: Evidence from Human Trials
Berberine activates AMPK through mild mitochondrial Complex I inhibition, producing improvements in glucose metabolism and modest weight loss in meta-analyses of clinical trials.
2026-02-18
Vitamin D3 and Telomere Attrition: Findings from the VITAL Randomized Trial
A VITAL sub-study (n=1,054, 4 years, 2,000 IU/day vitamin D3) found reduced leukocyte telomere attrition in the vitamin D group versus placebo. Omega-3 showed no significant effect. Telomere length is a surrogate marker; clinical outcome implications are uncertain.
2026-02-14
Carnosine: Glycation Buffering, Brain Aging, and Carnosinase Variability
Carnosine is a dipeptide that buffers glycation and carbonyl stress, with additional evidence for neuroprotection. Oral carnosine is cleaved by carnosinase — tissue uptake varies significantly by carnosinase genotype, which affects individual response.