Best Fit Profiles
- oxidative stress reduction and detoxification support; particularly useful when NAC is insufficient
Master antioxidant and detoxification
Glutathione
Glutathione is the primary endogenous antioxidant. Direct supplementation has poor oral bioavailability in standard form; liposomal and S-acetyl-glutathione forms show better absorption. NAC is often more cost-effective as a glutathione precursor.
Evidence Level B
Evidence and Risk Labels
Evidence A/B/C reflects research maturity, and risk levels reflect monitoring needs. These labels support comparison, not diagnosis or treatment decisions.
See full scoring guideClinical Snapshot
- Effect Size
- Meaningful oxidative stress reduction with bioavailable forms; modest compared to NAC in most contexts
- Safety
- Low Risk
Standard oral glutathione has low bioavailability; liposomal or reduced forms preferred. High doses may temporarily lower zinc absorption.
Research Dosing
This reflects common ranges and protocols used in published studies, not personal medical advice.
- Typical Daily Dose
- 250-500 mg (liposomal or S-acetyl form)
- Timing
- On empty stomach or between meals
- Protocol Duration in Studies
- 8-12 weeks; assess response via oxidative stress markers
NAC (N-acetylcysteine) is a more cost-effective route to glutathione in most cases.