2026-02-24
Grip Strength as a Longevity Biomarker: What It Predicts and How to Maintain It
Grip strength is a validated predictor of all-cause mortality, cardiovascular outcomes, and functional decline. This review covers the evidence base, what thresholds matter, and practical strategies to maintain grip and overall muscular capacity with age.
2026-02-24
Intermittent Fasting and Aging: Metabolic Benefits, Muscle Risk, and Evidence Review
Intermittent fasting (IF) protocols — including 16:8 time-restricted eating and 5:2 alternate-day approaches — produce modest metabolic benefits similar to matched caloric restriction. Autophagy induction is mechanistically plausible but not confirmed in humans at the cellular level during typical IF windows. Muscle mass preservation requires attention to protein timing and resistance training.
2026-02-20
Creatine Plus Protein in Older Adults: Strength and Frailty-Relevant Outcomes
In older adults, creatine and adequate protein show the most consistent benefit when paired with resistance training, with practical relevance for sarcopenia and fall-risk prevention.
2026-02-18
Rapamycin in Older Adults: PEARL Trial Findings on Dose, Sex Differences, and Body Composition
The PEARL trial tested low-dose weekly rapamycin in healthy older adults. The primary endpoint — visceral fat reduction — was not met. Secondary analyses suggested lean tissue effects at higher doses in women, but these require confirmation in adequately powered trials.
2026-02-18
CoQ10 and Mitochondrial Function: Age-Related Decline and Clinical Evidence
CoQ10 declines with age and statin exposure. Human evidence is strongest in heart failure and statin-associated muscle symptoms, while prevention use in healthy adults remains less certain.