2026-02-24
Vision and Age-Related Macular Degeneration: Lutein, Zeaxanthin, and AREDS2 Evidence
The AREDS2 trial established lutein and zeaxanthin as replacements for beta-carotene in the AMD supplement formula, reducing progression risk by 25% in high-risk eyes. Dietary intake from dark leafy greens provides equivalent carotenoids. This article explains what the evidence supports and what it does not.
2026-02-23
Copper and Zinc Balance: Enzymatic Roles, Aging-Related Shifts, and Supplementation Risks
Copper and zinc compete for absorption and must stay in balance. Zinc supplementation without copper co-dosing can induce copper deficiency, causing anemia and neurological symptoms. Aging shifts the Cu/Zn ratio and affects superoxide dismutase activity — monitoring both matters.
2026-02-22
Anemia and Iron Deficiency in Aging: Diagnosis, Causes, and Supplementation Evidence
Anemia affects 10–20% of adults over 65 and is independently associated with frailty, cognitive decline, and mortality. Iron deficiency is the most common cause but is often missed in older adults. Supplementation restores function when deficiency is confirmed — but iron excess is harmful and routine supplementation without deficiency is not indicated.
2026-02-12
Biomarker Testing Before Supplementing: B12, Vitamin D, Homocysteine, Ferritin, and CRP
Supplementing without baseline testing is guesswork. Vitamin D, B12, folate, ferritin, homocysteine, and hs-CRP are the most actionable starting points. This guide explains what each test reveals, what ranges mean, and which supplements to prioritize based on results.
2026-02-03
Eye Health and Macular Degeneration Prevention: AREDS2 Formula, Lutein, and Zeaxanthin
Age-related macular degeneration (AMD) is the leading cause of vision loss in older adults. The AREDS2 trial established that high-dose lutein, zeaxanthin, vitamins C and E, and zinc slow progression in intermediate-to-advanced AMD. Prevention evidence for early-stage disease is less definitive.