2026-02-24
Estrogen, Menopause, and Aging: Hormonal Mechanisms, Health Implications, and Protocol
Menopause-associated estrogen decline drives accelerated changes in cardiovascular risk, bone density, cognitive function, and metabolic health. Menopausal hormone therapy (MHT) has RCT and observational evidence supporting benefits for symptomatic relief and bone protection; cardiovascular and breast cancer risks depend on timing, type, and route of administration.
2026-02-24
GLP-1 Agonists and Aging: Metabolic Benefits, Cardiovascular Evidence, and Longevity Implications
GLP-1 receptor agonists like semaglutide have demonstrated cardiovascular and metabolic benefits beyond weight reduction. This review covers the mechanistic basis, major trial evidence, and the open questions about their role in longevity medicine.
2026-02-24
Grip Strength as a Longevity Biomarker: What It Predicts and How to Maintain It
Grip strength is a validated predictor of all-cause mortality, cardiovascular outcomes, and functional decline. This review covers the evidence base, what thresholds matter, and practical strategies to maintain grip and overall muscular capacity with age.
2026-02-24
Inflammaging: Chronic Low-Grade Inflammation in Aging, Causes, and Intervention Evidence
Inflammaging — the chronic low-grade inflammatory state that accumulates with age — is now recognized as a driver of virtually every major age-related disease. Senescent cells, gut dysbiosis, and visceral fat are the primary sources. Targeted interventions address the root causes, not just the biomarkers.
2026-02-24
Intermittent Fasting and Aging: Metabolic Benefits, Muscle Risk, and Evidence Review
Intermittent fasting (IF) protocols — including 16:8 time-restricted eating and 5:2 alternate-day approaches — produce modest metabolic benefits similar to matched caloric restriction. Autophagy induction is mechanistically plausible but not confirmed in humans at the cellular level during typical IF windows. Muscle mass preservation requires attention to protein timing and resistance training.