LongevityLeak

Condition Strategy

Chronic Kidney Disease

Slow GFR decline, manage cardiovascular risk, and prevent acute kidney injury

Evidence Level A

Evidence and Risk Labels

Evidence A/B/C reflects research maturity, and risk levels reflect monitoring needs. These labels support comparison, not diagnosis or treatment decisions.

See full scoring guide

Guidance Summary

CKD progression is driven by hypertension, diabetes, and chronic inflammation. Blood pressure control and avoiding nephrotoxic agents (including high-dose oxalate supplements and aristolochic acid) are the primary levers. Omega-3 and potassium citrate have supportive roles in specific contexts.

Top Interventions

  • blood pressure control to <130/80 mmHg
  • protein intake moderation in advanced CKD
  • sodium restriction
  • smoking cessation
  • nephrotoxin avoidance

Monitoring Priorities

  • eGFR (estimated GFR)
  • urine albumin-to-creatinine ratio
  • blood pressure log
  • electrolytes and bicarbonate
  • hemoglobin

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