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Browse evidence-ranked supplements and condition protocols.
Evidence-first updates
Standard lab ranges were built for diagnosis, not longevity optimization.
Each week we review clinical studies on bloodwork, supplements, and longevity protocols with clear evidence strength, uncertainty, and risk context.
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Blood sugarCRITICAL
HbA1c
Optimal: below 5.3% — not 6.5%
InflammationHIGH IMPACT
hsCRP
Inflammation's hidden damage threshold
HormonesCRITICAL
IGF-1
The growth axis that predicts cancer + longevity
CardiovascularHIGH IMPACT
Homocysteine
Cardiovascular risk your GP routinely ignores
MicronutrientsMEDIUM
Vitamin D (25-OH)
Deficiency in 40% of adults — optimal ≠ sufficient
MetabolicCRITICAL
Fasting insulin
Diabetes risk a decade before glucose spikes
LipidsHIGH IMPACT
ApoB
Better cardiac risk predictor than LDL cholesterol
LiverMEDIUM
ALT / AST
Liver stress signal most panels dismiss too easily
KidneyHIGH IMPACT
eGFR
Kidney function declines silently for years first
HormonesMEDIUM
Testosterone (free)
Free T predicts energy, mood & metabolic risk
ThyroidHIGH IMPACT
TSH + Free T3/T4
Thyroid range 'normal' misses early dysfunction
HormonesMEDIUM
DHEA-S
Adrenal reserve and biological ageing marker
Blood sugarCRITICAL
HbA1c
Optimal: below 5.3% — not 6.5%
InflammationHIGH IMPACT
hsCRP
Inflammation's hidden damage threshold
HormonesCRITICAL
IGF-1
The growth axis that predicts cancer + longevity
CardiovascularHIGH IMPACT
Homocysteine
Cardiovascular risk your GP routinely ignores
MicronutrientsMEDIUM
Vitamin D (25-OH)
Deficiency in 40% of adults — optimal ≠ sufficient
MetabolicCRITICAL
Fasting insulin
Diabetes risk a decade before glucose spikes
LipidsHIGH IMPACT
ApoB
Better cardiac risk predictor than LDL cholesterol
LiverMEDIUM
ALT / AST
Liver stress signal most panels dismiss too easily
KidneyHIGH IMPACT
eGFR
Kidney function declines silently for years first
HormonesMEDIUM
Testosterone (free)
Free T predicts energy, mood & metabolic risk
ThyroidHIGH IMPACT
TSH + Free T3/T4
Thyroid range 'normal' misses early dysfunction
HormonesMEDIUM
DHEA-S
Adrenal reserve and biological ageing marker